Montgomery-Asberg Depression Rating Scale

The Montgomery-Asberg Depression Rating Scale (MADRS) is a gold-standard, clinician-administered instrument designed to assess the severity of depressive…

Montgomery-Asberg Depression Rating Scale
Questions
10
Duration
15 min
Original title
MADRS — Montgomery–Åsberg Depression Rating Scale
Adaptation
Montgomery-Asberg Depression Rating Scale
Authors
Montgomery, S.A. & Åsberg, M.
Created
1979

The Montgomery-Asberg Depression Rating Scale (MADRS) is a gold-standard, clinician-administered instrument designed to assess the severity of depressive episodes in adult patients. Originally developed to be highly sensitive to symptom change over time, it is heavily utilized in both psychopharmacological research and routine measurement-based care. The scale prioritizes psychological and cognitive symptoms, such as anhedonia, pervasive sadness, and pessimistic thoughts, over somatic complaints. This targeted focus helps to untangle the core features of depression from concurrent medical conditions in physically ill populations.

Unlike self-report questionnaires, the MADRS relies on a semi-structured clinical interview, allowing the clinician to probe broadly before narrowing down to establish precise severity ratings. This clinical scaffolding ensures reliable symptom capture even when patients struggle to articulate their internal state. By generating a continuous severity metric, it provides an objective framework to monitor therapeutic efficacy, alerting clinicians early if a pharmacological or psychological intervention requires adjustment.

Example result

Fictitious result, computed from a sample set of answers.

Overall score
24/ 60
A 10-item clinician-administered rating scale designed to measure the severity of depressive symptoms in adults and to monitor their trajectory under treatment. Rated by a clinician following a clinical interview, it emphasizes the psychological symptoms of depression and is particularly sensitive to therapeutic change.
0–6
normal / no symptoms
7–19
mild
20–30
moderate
24
31–39
severe
40–60
extremely severe
Depression severity descriptor
Scoring
Sum, total score from 0 to 60, each item is rated on a 7-point scale (from 0 to 6).

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What the test measures

The MADRS quantifies the depth and severity of depressive symptomatology based on a standardized clinical interview. The ten items cover a concentrated set of core depressive criteria:

  • Observable distress: Apparent sadness reflected in speech, posture, and facial expression.
  • Subjective mood: Patient-reported sadness, despondency, and gloom.
  • Anxiety and tension: Inner tension, edginess, and unrelenting dread.
  • Neurovegetative shifts: Reduced sleep and loss of appetite.
  • Cognitive impairment: Concentration difficulties and inability to collect one's thoughts.
  • Volitional deficits: Lassitude, sluggishness, and difficulty initiating routine activities.
  • Anhedonia and numbness: Inability to feel appropriate emotion for circumstances or close relationships.
  • Cognitive distortions: Pessimistic thoughts, persistent self-accusation, guilt, and rigid all-or-nothing thinking.
  • Suicidality: Suicidal thoughts, world-weariness, and active preparation.

The instrument is validated for adults experiencing major depressive episodes across outpatient, inpatient, and clinical trial settings.

When and why to use it

Clinicians integrate the MADRS into practice to establish baseline severity and rigorously track treatment response over time. It is indicated in the following clinical scenarios:

  • Intake baseline: To quantify the initial depth of a depressive episode before initiating pharmacotherapy or psychotherapy.
  • Monitoring change: To track week-to-week symptom trajectory, as the instrument is exceptionally sensitive to treatment-induced shifts.
  • Treatment evaluation: To determine whether an ongoing intervention, such as behavioral activation via an activity menu, is achieving remission or if a dosage or modality change is warranted.
  • Differential support: To distinguish the core psychological burden of depression from somatic symptoms in medically complex patients or those with bipolar disorder.

Using a validated continuous score provides an objective, standardized metric of clinical progress that surpasses the reliability of global clinical impression alone.

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The questions

  1. The rating should be based on a clinical interview moving from broadly phrased questions about symptoms to more detailed ones which allow a precise rating of severity. The rater must decide whether the rating lies on the defined scale steps (0, 2, 4, 6) or between them (1, 3, 5). It is important to remember that it is only on rare occasions that a depressed patient is encountered who cannot be rated on the items in the scale. If definite answers cannot be elicited from the patient, all relevant clues as well as information from other sources should be used as a basis for the rating in line with customary clinical practice. Tick the box corresponding to the most appropriate number for each item.
    1. Apparent Sadness — Represents despondency, gloom, and despair (more than just passing blues) reflected in speech, facial expression, and posture. Rate according to depth and inability to brighten up. 0: No sadness; 2: Looks despondent but can brighten up without difficulty; 4: Appears sad and unhappy most of the time; 6: Looks miserable all the time, extremely despondent.
    This item assesses the outward, observable signs of depressed mood in the patient's demeanor and nonverbal communication.
    • 0
    • 1 (intermediate)
    • 2
    • 3 (intermediate)
    • 4
    • 5 (intermediate)
    • 6
  2. 2. Reported Sadness — Represents reports of a depressed mood, regardless of whether it is apparent. Includes feeling down, despondent, or a feeling of hopeless distress. Rate according to intensity, duration, and the extent to which mood is said to be influenced by events. 0: Occasional sadness in keeping with the circumstances; 2: Sad or down, but brightens up without difficulty; 4: Pervasive feeling of sadness or depression; mood is still influenced by external circumstances; 6: Continuous or unvarying sadness, despair, or despondency.
    This item evaluates the patient's subjective description of their own low mood and sense of hopelessness.
    • 0
    • 1 (intermediate)
    • 2
    • 3 (intermediate)
    • 4
    • 5 (intermediate)
    • 6
  3. 3. Inner Tension — Represents feelings of ill-defined discomfort, irritability, inner turmoil, and nervous tension ranging to panic, dread, or anguish. Rate according to intensity, frequency, duration, and the need for reassurance. 0: Calm, only passing inner tension; 2: Occasional feelings of irritability and ill-defined discomfort; 4: Continuous feelings of inner tension or intermittent panic that the patient can only master with difficulty; 6: Unrelenting dread or anguish, overwhelming panic.
    This item gauges the intensity of the patient's internal psychological distress, anxiety, and dread.
    • 0
    • 1 (intermediate)
    • 2
    • 3 (intermediate)
    • 4
    • 5 (intermediate)
    • 6
  4. 4. Reduced Sleep — Represents a reduction in sleep duration or depth compared to the patient's sleep when not ill. 0: Sleeps as usual; 2: Slight difficulty falling asleep or slightly reduced, light, or restless sleep; 4: Sleep reduced or interrupted by at least two hours; 6: Less than two or three hours of sleep.
    This item measures the extent to which the patient's sleep duration or depth has decreased compared to their healthy baseline.
    • 0
    • 1 (intermediate)
    • 2
    • 3 (intermediate)
    • 4
    • 5 (intermediate)
    • 6
  5. 5. Reduced Appetite — Represents the feeling of a loss of appetite compared to usual. Rate the absence of a desire for food or the need to force oneself to eat. 0: Normal or increased appetite; 2: Slightly reduced appetite; 4: No appetite, food is tasteless; 6: Eats only if persuaded.
    This item captures the degree of appetite loss and the physical effort required for the patient to consume food.
    • 0
    • 1 (intermediate)
    • 2
    • 3 (intermediate)
    • 4
    • 5 (intermediate)
    • 6
  6. 6. Concentration Difficulties — Represents difficulties in gathering one's thoughts up to an inability to concentrate. Rate the intensity, frequency, and degree of incapacity. 0: No difficulties concentrating; 2: Occasional difficulties in gathering one's thoughts; 4: Difficulties in concentrating and sustaining attention, which reduces the ability to read or hold a conversation; 6: Unable to read or converse without great difficulty.
    This item probes the cognitive impact of depression by evaluating the patient's ability to focus, read, or sustain a conversation.
    • 0
    • 1 (intermediate)
    • 2
    • 3 (intermediate)
    • 4
    • 5 (intermediate)
    • 6
  7. 7. Lassitude — Represents a difficulty getting started or slowness in initiating and performing daily activities. 0: Hardly any difficulty getting started, no slowness; 2: Difficulties starting activities; 4: Difficulties starting routine activities which are continued with effort; 6: Great lassitude, unable to do anything without help.
    This item focuses on psychomotor retardation and the subjective difficulty the patient experiences when initiating daily tasks.
    • 0
    • 1 (intermediate)
    • 2
    • 3 (intermediate)
    • 4
    • 5 (intermediate)
    • 6
  8. 8. Inability to Feel — Represents the subjective experience of reduced interest in the surroundings or in activities that normally give pleasure. The ability to react with appropriate emotion to circumstances or people is reduced. 0: Normal interest in the surroundings and in people; 2: Reduced ability to enjoy usual interests; 4: Loss of interest in the surroundings, loss of feeling for friends and acquaintances; 6: Feeling emotionally paralyzed, unable to feel anger, grief, or pleasure, and a complete or even painful inability to feel anything for close relatives and friends.
    This item evaluates affective flattening and the loss of emotional resonance regarding normally pleasurable activities or close relationships.
    • 0
    • 1 (intermediate)
    • 2
    • 3 (intermediate)
    • 4
    • 5 (intermediate)
    • 6
  9. 9. Pessimistic Thoughts — Represents ideas of guilt, inferiority, self-reproach, sin, remorse, or ruin. 0: No pessimistic thoughts; 2: Intermittent ideas of failure, self-reproach, or self-deprecation; 4: Persistent self-accusations, or specific but still rational ideas of guilt or sin; growing pessimism about the future; 6: Delusions of ruin, remorse, or unpardonable sin; absurd or unshakable self-accusations.
    This item assesses the presence and rigidity of depressive cognitive distortions, including guilt, self-reproach, and perceived ruin.
    • 0
    • 1 (intermediate)
    • 2
    • 3 (intermediate)
    • 4
    • 5 (intermediate)
    • 6
  10. 10. Suicidal Thoughts — Represents the feeling that life is not worth living, that a natural death would be welcome, suicidal thoughts, and preparations for suicide. Suicide attempts themselves should not influence the rating. 0: Enjoys life or takes it as it comes; 2: Tired of life, only fleeting suicidal thoughts; 4: It would be better to be dead; suicidal thoughts are common, and suicide is considered a possible solution but without any specific plan or intent; 6: Explicit plans for suicide if the opportunity arises; suicide preparations.
    This item determines the imminence and severity of suicidal ideation, ranging from a passive wish for death to active planning.
    • 0
    • 1 (intermediate)
    • 2
    • 3 (intermediate)
    • 4
    • 5 (intermediate)
    • 6
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